Clinicopathological features of Adult Granulosa Cell Tumour of Ovary- A Case Series of 14 Cases

Abstract

Adult Granulosa Cell Tumour (AGCT) is the most common sex cord stromal tumour of ovaries. These tumours in comparison with epithelial tumours are of low-grade malignant potential and have low recurrence rate after surgical procedure. In this case series, a retrospective search for ovarian AGCT cases from January 2016 till January 2021 was done. A total of 14 cases were included. Parameters studied in this case series were age, laterality, gross, architectural pattern, call Exner bodies, nuclear grooves, necrosis, mitotic count and tumour staging. After studying all the cases, it was reported that mean age of presentation was 44 years (range 21-64 years), unilateral with right-sided dominance (71.4%), grossly 78.5% of the cases were solid cystic with haemorrhagic area, with mean tumour size of 9 cm, 57.1% cases had call Exner bodies, and all the cases showed nuclear groves. Most of the cases, 85.7% presented with low mitotic count of <4/10 High Power Field (HPF). Rare presentation of endometroid carcinoma-endometrium World Health Organisation (WHO) Female Genital Tract (FGT) fifth edition), and mature teratoma of contralateral ovary presented in one case each. This case series outlines characteristic histomorphological feature, frequent presentation at lower stage, and low mitotic count, these characteristic features act as prognostic marker for recurrence prediction.

Keywords

• ovarian
• pattern
• prognosis
• stage
• stromal tumour