Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation

Shunsuke Hasegawa; Hotaka Fukushima; Hiroshi Hosoda; Tatsurou Serita; Rie Ishikawa; Tomohiro Rokukawa; Ryouka Kawahara-Miki; Yue Zhang; Miho Ohta; Shintaro Okada; Toshiyuki Tanimizu; Sheena A. Josselyn; Paul W. Frankland; Satoshi Kida

doi:10.1038/s41467-019-13554-y

Nature Communications (Dec 2019)

Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation

Shunsuke Hasegawa,
Hotaka Fukushima,
Hiroshi Hosoda,
Tatsurou Serita,
Rie Ishikawa,
Tomohiro Rokukawa,
Ryouka Kawahara-Miki,
Yue Zhang,
Miho Ohta,
Shintaro Okada,
Toshiyuki Tanimizu,
Sheena A. Josselyn,
Paul W. Frankland,
Satoshi Kida

Affiliations

Shunsuke Hasegawa: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Hotaka Fukushima: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Hiroshi Hosoda: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Tatsurou Serita: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Rie Ishikawa: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Tomohiro Rokukawa: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Ryouka Kawahara-Miki: NODAI Genome Research Center, Tokyo University of Agriculture
Yue Zhang: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Miho Ohta: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Shintaro Okada: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Toshiyuki Tanimizu: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture
Sheena A. Josselyn: Department of Physiology, Faculty of Medicine, University of Toronto
Paul W. Frankland: Department of Physiology, Faculty of Medicine, University of Toronto
Satoshi Kida: Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture

DOI: https://doi.org/10.1038/s41467-019-13554-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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