Updates on the research and management of pancreatic neuroendocrine neoplasm in 2021

Abstract

Pancreatic neuroendocrine neoplasm (PanNEN) has a low incidence and strong heterogeneity. Research on molecular mechanism of PanNEN is gradually increasing. At the same time, the updates on clinical diagnosis, treatment and prognosis prediction of PanNEN patients are increasing. In addition to surgery and systemic treatment such as somatostatin analogs and tyrosine kinase inhibitors, there are unsolved problems and questions in the management of PanNEN patients, which emphasizes individualized treatment and multidisciplinary treatment. This article summarized the basic and clinical research progress of PanNEN in 2021.

Keywords

• |pancreatic neuroendocrine tumor|molecular marker|diagnosis|prognosis|treatment