Association analyses of nutritional markers with Parkinson’s disease and Alzheimer’s disease
Dong-Juan Xu,
Yi-Lei Shen,
Meng-Meng Hu,
Ling-Ling Li,
Yuan Fang,
Ju-Ping He,
Lu-Lu Ma,
Shan-Shan Xu,
Jian-Yong Wang
Affiliations
Dong-Juan Xu
Department of Neurology, Dongyang Affiliated Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
Yi-Lei Shen
Department of Neurology, Dongyang Affiliated Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
Meng-Meng Hu
Department of Neurology, Dongyang Affiliated Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
Ling-Ling Li
Department of Neurology, Dongyang Affiliated Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
Yuan Fang
Department of Neurology, Dongyang Affiliated Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
Ju-Ping He
Department of Neurology, Dongyang Affiliated Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
Lu-Lu Ma
Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
Shan-Shan Xu
Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
Jian-Yong Wang
Department of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; Corresponding author. Department of Neurology, the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Introduction: Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative diseases with multifaceted etiology. Nutritional and metabolic abnormalities are frequently implicated in PD and AD. In this observational study, we analyzed a series of nutritional markers, and aimed to understand their association with AD and PD risk. Methods: A total of 424 PD patients, 314 AD patients, and 388 healthy controls were included. Nutritional markers including Hemoglobin A1c, vitamin B12, folate, apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, total cholesterol (TC), uric acid and homocysteine (HCY) were measured. Significance for odds ratios examining was P < 0.0045 after bonferroni correction. Results: Multifactor risk analysis showed that ApoB, LDL, and TC reduce PD risk, while HCY increase PD risk. ApoA1 and HCY are protective and risk factors for AD, respectively. Conclusion: The cross-sectional study demonstrates that HCY and lipid metabolism markers are associated with PD and AD risks. Our findings support the involvement of one-carbon metabolism and lipid metabolism disturbance in PD and AD.
