Nature Communications (May 2020)
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours
- Peter A. Johansson,
- Kelly Brooks,
- Felicity Newell,
- Jane M. Palmer,
- James S. Wilmott,
- Antonia L. Pritchard,
- Natasa Broit,
- Scott Wood,
- Matteo S. Carlino,
- Conrad Leonard,
- Lambros T. Koufariotis,
- Vaishnavi Nathan,
- Aaron B. Beasley,
- Madeleine Howlie,
- Rebecca Dawson,
- Helen Rizos,
- Chris W. Schmidt,
- Georgina V. Long,
- Hayley Hamilton,
- Jens F. Kiilgaard,
- Timothy Isaacs,
- Elin S. Gray,
- Olivia J. Rolfe,
- John J. Park,
- Andrew Stark,
- Graham J. Mann,
- Richard A. Scolyer,
- John V. Pearson,
- Nicolas van Baren,
- Nicola Waddell,
- Karin W. Wadt,
- Lindsay A. McGrath,
- Sunil K. Warrier,
- William Glasson,
- Nicholas K. Hayward
Affiliations
- Peter A. Johansson
- QIMR Berghofer Medical Research Institute
- Kelly Brooks
- QIMR Berghofer Medical Research Institute
- Felicity Newell
- QIMR Berghofer Medical Research Institute
- Jane M. Palmer
- QIMR Berghofer Medical Research Institute
- James S. Wilmott
- Melanoma Institute Australia, The University of Sydney
- Antonia L. Pritchard
- QIMR Berghofer Medical Research Institute
- Natasa Broit
- QIMR Berghofer Medical Research Institute
- Scott Wood
- QIMR Berghofer Medical Research Institute
- Matteo S. Carlino
- Melanoma Institute Australia, The University of Sydney
- Conrad Leonard
- QIMR Berghofer Medical Research Institute
- Lambros T. Koufariotis
- QIMR Berghofer Medical Research Institute
- Vaishnavi Nathan
- QIMR Berghofer Medical Research Institute
- Aaron B. Beasley
- School of Medical and Health Sciences, Edith Cowan University
- Madeleine Howlie
- QIMR Berghofer Medical Research Institute
- Rebecca Dawson
- QIMR Berghofer Medical Research Institute
- Helen Rizos
- Melanoma Institute Australia, The University of Sydney
- Chris W. Schmidt
- QIMR Berghofer Medical Research Institute
- Georgina V. Long
- Melanoma Institute Australia, The University of Sydney
- Hayley Hamilton
- QIMR Berghofer Medical Research Institute
- Jens F. Kiilgaard
- Department of Ophthalmology, Rigshospitalet-Glostrup Hospital, University of Copenhagen
- Timothy Isaacs
- Perth Retina
- Elin S. Gray
- School of Medical and Health Sciences, Edith Cowan University
- Olivia J. Rolfe
- Queensland Ocular Oncology Service, The Terrace Eye Centre
- John J. Park
- Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University
- Andrew Stark
- Queensland Ocular Oncology Service, The Terrace Eye Centre
- Graham J. Mann
- Melanoma Institute Australia, The University of Sydney
- Richard A. Scolyer
- Melanoma Institute Australia, The University of Sydney
- John V. Pearson
- QIMR Berghofer Medical Research Institute
- Nicolas van Baren
- Ludwig Institute for Cancer Research
- Nicola Waddell
- QIMR Berghofer Medical Research Institute
- Karin W. Wadt
- Department of Clinical Genetics, Rigshospitalet
- Lindsay A. McGrath
- Queensland Ocular Oncology Service, The Terrace Eye Centre
- Sunil K. Warrier
- Queensland Ocular Oncology Service, The Terrace Eye Centre
- William Glasson
- Queensland Ocular Oncology Service, The Terrace Eye Centre
- Nicholas K. Hayward
- QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-16276-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 8
Abstract
Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a UV exposure signature.
