Scientific Reports (Jun 2023)

Inflammatory biomarkers at different stages of Sarcopenia in older women

  • Leonardo Augusto da Costa Teixeira,
  • Nubia Carelli Pereira Avelar,
  • Marco Fabrício Dias Peixoto,
  • Adriana Netto Parentoni,
  • Jousielle Marcia dos Santos,
  • Fabiana Souza Máximo Pereira,
  • Ana Lúcia Danielewicz,
  • Amanda Aparecida Oliveira Leopoldino,
  • Sabrina Paula Costa,
  • Arthur Nascimento Arrieiro,
  • Luana Aparecida Soares,
  • Vanessa Kelly da Silva Lage,
  • Ana Caroline Negreiro Prates,
  • Redha Taiar,
  • Alessandra de Carvalho Bastone,
  • Vinicius Cunha de Oliveira,
  • Murilo Xavier Oliveira,
  • Henrique Silveira Costa,
  • Juliana Nogueira Pontes Nobre,
  • Franciane Pereira Brant,
  • Tamiris Campos Duarte,
  • Pedro Henrique Scheidt Figueiredo,
  • Vanessa Amaral Mendonça,
  • Ana Cristina Rodrigues Lacerda

DOI
https://doi.org/10.1038/s41598-023-37229-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 8

Abstract

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Abstract In recent years, studies have found that Sarcopenia alters inflammatory biomarkers. However, the behavior of inflammatory biomarkers at different stages of Sarcopenia is not well understood. This study aimed to compare a broad panel of inflammatory biomarkers in older women at different stages of Sarcopenia. The study included 71 Brazilian community-dwelling older women. Muscle Strength was assessed by using handgrip strength (Jamar dynamometer). The Short Physical Performance Battery (SPPB) was performed to assess the physical performance, and body composition was assessed by DEXA. Sarcopenia was diagnosed and classified according to the EWGSOP2 criteria. Blood was drawn, and inflammatory biomarkers associated with Sarcopenia (IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNF, adiponectin, leptin, resistin, BDNF, sTNFr-1 and sTNFr-2) was analysed. After diagnosis and classification of sarcopenia, 45% of women did not present Sarcopenia (NS, N = 32), 23.9% were diagnosed with Sarcopenia Probable (SP, N = 17), 19,7% with Sarcopenia Confirmed (SC, N = 14), and 11.3% with Severe Sarcopenia (SS, N = 8). The analysis of inflammatory biomarkers revealed that the more advanced the stage of Sarcopenia, the higher the levels of BDNF, IL-8, sTNFr-1, and sTNFr-2. The assessment of BDNF, IL-8, sTNFr-1, and sTNFr-2 levels may be an adjuvant tool in diagnosis and severity classification of Sarcopenia in older Brazilian women.