Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.
Hiyoung Kim,
Kwang-Jin Kim,
Jeong-Tae Yeon,
Seong Hwan Kim,
Dong Hwan Won,
Hyukjae Choi,
Sang-Jip Nam,
Young-Jin Son,
Heonjoong Kang
Affiliations
Hiyoung Kim
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea
Kwang-Jin Kim
Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea
Jeong-Tae Yeon
Research Institute of Basic Science, Sunchon National University, Suncheon 540-742, Korea
Seong Hwan Kim
Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea
Dong Hwan Won
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea
Hyukjae Choi
College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea
Sang-Jip Nam
Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea
Young-Jin Son
Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea
Heonjoong Kang
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea
A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.
