Progress on clinical prognosis assessment in liver failure

Abstract

Liver failure is a group of clinical syndromes with a mortality rate of >50%. The accurate evaluation of severity in patients with liver failure has been a meaningful and hot topic in clinical research and an important guide for liver transplantation. Numerous prognosis studies have emerged in recent years with high accuracy and adequate validity. Nonetheless, different models utilize distinct parameters and have unequal efficiencies, leading to a specific value and unique application situations for each model. This review focused on the progress in recent prognostic studies including the model for end-stage liver disease, sequential organ failure assessment and its derivative models, the Chinese Group on the Study of Severe Hepatitis B Acute-on-Chronic Liver Failure, the Tongji prognostic predictor model, and other emerging prognostic models and predictors. This review aims to assist clinicians understand the framework of recent models and choose the appropriate model and treatment.

Keywords

• Liver failure (LF)
• Prognosis
• Model for end-stage liver disease (MELD)
• Sequential organ failure assessment (SOFA)
• Chinese Group on the Study of Severe Hepatitis B Acute-on-Chronic LF (COSSH-ACLF)
• Tongji prognostic predictor model (TPPM)