Chronic-Relapsing cutaneous leukocytoclastic vasculitis in a young patient with reduced EBV-specific T cell response using enzyme-linked immunospot (ELISPOT) assay successfully treated with Valaciclovir
Caterina Foti,
Elvira Favoino,
Maria Scarasciulli,
Anna Maria Colacicco,
Hamidreza Jahantigh,
Angela Stufano,
Piero Lovreglio,
Paola Mascia,
Chiara Barlusconi,
Federico Perosa,
Paolo Romita,
Agata Calvario
Affiliations
Caterina Foti
Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy; Corresponding author.
Elvira Favoino
Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy
Maria Scarasciulli
Microbiology and Virology Unit - Interdisciplinary Department of Medicine (DIM) - University of Bari ''Aldo Moro''- AOU Policlinico Bari, Italy
Anna Maria Colacicco
Microbiology and Virology Unit - Interdisciplinary Department of Medicine (DIM) - University of Bari ''Aldo Moro''- AOU Policlinico Bari, Italy
Hamidreza Jahantigh
Interdisciplinary Department of Medicine, University of Bari ''Aldo Moro'', 70124 Bari, Italy
Angela Stufano
Interdisciplinary Department of Medicine, University of Bari ''Aldo Moro'', 70124 Bari, Italy
Piero Lovreglio
Interdisciplinary Department of Medicine, University of Bari ''Aldo Moro'', 70124 Bari, Italy
Paola Mascia
Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy
Chiara Barlusconi
Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy
Federico Perosa
Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy
Paolo Romita
Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari “Aldo Moro”, Bari, Italy
Agata Calvario
Microbiology and Virology Unit - Interdisciplinary Department of Medicine (DIM) - University of Bari ''Aldo Moro''- AOU Policlinico Bari, Italy
Among different pathogens, opportunistic viral infection caused by EBV is particularly relevant. This gammaherpesvirus, belonging to the Herpesviridae family, may complicate the disease course in different clinical settings by inducing pathological EBV pictures in patients with a defective immunologic response. Our report evaluated EBV-specific T cell responses by IFN- γ ELISPOT assay, which revealed defective EBV specific immunological response.
