Molecular Cancer (Oct 2011)

L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer

  • Weder Walter,
  • Sos Martin L,
  • Bonde Anne-Katrine,
  • Kristiansen Glen,
  • Schirmer Uwe,
  • Hausladen Silke,
  • Pfeifer Marco,
  • Tischler Verena,
  • Moch Holger,
  • Altevogt Peter,
  • Soltermann Alex

DOI
https://doi.org/10.1186/1476-4598-10-127
Journal volume & issue
Vol. 10, no. 1
p. 127

Abstract

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Abstract Background The L1 cell adhesion molecule (L1CAM) is potentially involved in epithelial-mesenchymal transition (EMT). EMT marker expression is of prognostic significance in non-small cell lung cancer (NSCLC). The relevance of L1CAM for NSCLC is unclear. We investigated the protein expression of L1CAM in a cohort of NSCLC patients. L1CAM protein expression was correlated with clinico-pathological parameters including survival and markers of epithelial-mesenchymal transition. Results L1CAM protein expression was found in 25% of squamous cell carcinomas and 24% of adenocarcinomas and correlated with blood vessel invasion and metastasis (p Conclusions A subset of NSCLCs with vessel tropism and increased metastasis aberrantly expresses L1CAM. L1CAM is a novel prognostic marker for NSCLCs that is upregulated by EMT induction and appears to be instrumental for enhanced cell invasion.

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