Indolylimidazoles: Synthetic approaches and biological activities

Abstract

Indolylimidazole compounds that contain both indole and imidazole rings have shown various biological and pharmacological activities. These indolylimidazole compounds have been synthesized and extracted from the plants. In this paper, we have reviewed biological activities of natural and synthesized indolylimidazoles and their various synthetic methods. In recent time, the substituted indolylimidazole derivatives have synthesized and reported in the presence of different kind of the catalysts such as strong protic acid HNO3@nano SiO2, Zn2+@KSF and acetic acid and Amberlyst A-15. This review paper is divided into two categories bases on bioactivities of natural and synthesized indolylimidazole derivatives.

Keywords

• Imidazole
• Pharmacological activities
• Anticancer
• Amberlyst A-15
• Microwave irradiation