Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies

Abstract

Highlights Verbenone, a natural bicyclic ketone monoterpene, and L-arginine, a natural amino acid, are both found in Daucus carota and other medicinal plants useful in the management of diabetes mellitus. Verbenone and L-arginine possess in vitro antidiabetic activities, improve glucose uptake, and inhibited haemoglobin glycation. Verbenone possesses in vivo antidiabetic activities in NAD-STZ-induced diabetic mice with potential synergetic effect with L-arginine. Verbenone and L-arginine possess antihyperlipidemic properties and could prevent the risk of cardiovascular diseases in NAD-STZ-treated mice.

Keywords

• Antidiabetic
• Diabetes mellitus
• Verbenone
• L-arginne
• In vitro
• In vivo