Molecules (Jan 2013)

Graphite-Supported Perchloric Acid (HClO4-C): An Efficient and Recyclable Heterogeneous Catalyst for the One-Pot Synthesis of Amidoalkyl Naphthols

  • Zhen-Kai Lei,
  • Li Xiao,
  • Xiao-Quan Lu,
  • He Huang,
  • Chen-Jiang Liu

DOI
https://doi.org/10.3390/molecules18021653
Journal volume & issue
Vol. 18, no. 2
pp. 1653 – 1659

Abstract

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An efficient and direct protocol for the preparation of amidoalkylnaphthols employing a multi-component, one-pot condensation reaction of 2-naphthol, aromatic aldehydes and acetamide or benzamide in the presence of graphite supported perchloric acid under solvent-free conditions is described. The thermal solvent-free procedure offers advantages such as simple work-up, shorter reaction times and higher product yields, and the catalyst exhibited remarkable reactivity and can be recycled.

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