Platelet-rich fibrin: Current trends in periodontal regeneration

Abstract

Autologous platelet concentrates (APCs) have witnessed a sharp rise in popularity in recent years due to their low cost and ability to promote tissue neoangiogenesis. Platelet-rich fibrin (PRF) is a platelet concentrate (PC) generated from the patient’s blood without anticoagulants. PRF is a platelet-based condensation of suspended growth factors. It also has a substantial fibrin network, many leukocytes, cytokines, and glycoproteins and is used for tissue and bone regeneration. PRF plays a substantial role in wound healing. Based on the leucocyte and fibrin concentrations of PCs. Dohan Ehrenfest categorized PCs into four groups. L-PRF was used in the clot formation to fill the defect and in the membrane cover. Since then, studies, technological advances and manufacturing protocols have created newer forms and enhanced their potential as regenerative materials in numerous disciplines. In endosseous and furcation deformities, new APC varieties are being explored as biological mediators of regeneration. A computerized search of the PubMed and Google Scholar databases was performed to select relevant articles from 2006 to 2022. Screening of English language systematic reviews, meta-analyses, original research, and narrative reviews were considered in synthesizing this review. Primary subject headings like PRF, platelet-rich plasma, PCs, growth factors and PRF, periodontal regeneration and PCs were combined using Boolean ‘and’ with secondary terms like types, preparation, furcation, recession and intrabony defects.

Keywords

• platelet-rich plasma
• platelet-rich fibrin
• growth factors
• platelet concentrates
• regeneration
• autologous platelet concentrates