Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes <i>Perenniporia centrali-africana</i> and <i>Cerrena</i> sp. nov
Paomephan Pathompong,
Sebastian Pfütze,
Frank Surup,
Thitiya Boonpratuang,
Rattaket Choeyklin,
Josphat C. Matasyoh,
Cony Decock,
Marc Stadler,
Chuenchit Boonchird
Affiliations
Paomephan Pathompong
Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Sebastian Pfütze
Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Frank Surup
Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Thitiya Boonpratuang
National Biobank of Thailand (NBT), The National Science and Technology for Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand
Rattaket Choeyklin
National Biobank of Thailand (NBT), The National Science and Technology for Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand
Josphat C. Matasyoh
Department of Chemistry, Egerton University, P.O. Box 536, Njoro 20115, Kenya
Cony Decock
Earth and Life Institute, Mycothéque de l’ Universite Catholique de Louvain (BCCM/MUCL), Place Croix du Sud 3, B-1348 Louvain-la-Neuve, Belgium
Marc Stadler
Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Chuenchit Boonchird
Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,7-Dehydro-isodrimenediol (3) were isolated from P. centrali-africana. In parallel, the two new drimane-type sesquiterpene lactams 5 and 6 were isolated together with known isodrimenediol (4) from Cerrena sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities.
