Journal of Multidisciplinary Healthcare (Jul 2022)

Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic

  • Tangjittipokin W,
  • Srisawat L,
  • Teerawattanapong N,
  • Narkdontri T,
  • Homsanit M,
  • Plengvidhya N

Journal volume & issue
Vol. Volume 15
pp. 1585 – 1594

Abstract

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Watip Tangjittipokin,1,2 Lanraphat Srisawat,1– 3 Nipaporn Teerawattanapong,1– 3 Tassanee Narkdontri,1– 3 Mayuree Homsanit,4 Nattachet Plengvidhya2,5 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), Faculty of Medicine Siriraj, Mahidol University, Bangkok, Thailand; 3Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 5Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Nattachet Plengvidhya, Division of Endocrinology and Metabolism, Department of Medicine Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand, Tel +66 2-416-7797, Fax +66 2-419-7792, Email [email protected]: This study investigated the prevalence and characteristics of prediabetes (PreDM) and metabolic syndrome (MetS) in seemingly healthy persons attending a health check-up clinic at a tertiary care hospital.Patients and Methods: This was a cross-sectional study that enrolled 1213 subjects (339 male, 874 female) who underwent an annual health check-up at Siriraj Hospital, Bangkok, Thailand from 2009 to 2019. Factors that independently related to PreDM were analyzed using unconditional logistic regression analysis with adjustments for age, BMI, and gender.Results: The prevalence of PreDM and MetS was 54.3% and 19.7% respectively. Participants with impaired fasting glucose (IFG) and glycated hemoglobin (HbA1c) 38.8– 46.4 mmol/mol had significantly higher waist circumference (WC) and blood pressure (BP) compared to those with IFG or HbA1c 38.8– 46.4 mmol/mol alone (P < 0.05). Among three PreDM subgroups, the average age was lowest in the HbA1c 38.8– 46.4 mmol/mol subgroup (P < 0.001). PreDM participants with MetS were older (p = 0.03), had higher WC, BP, fasting plasma glucose and serum triglyceride level (all P < 0.001) but had lower serum high-density lipoprotein (HDL) cholesterol level (P < 0.001). Multivariate analysis revealed high MetS score, obesity, and low serum HDL cholesterol level to be independently associated with PreDM with odds ratios of 9.02 (95% confidence interval [CI]: 4.03– 20.18), 1.8 (95% CI: 1.07– 3.04), and 1.42 (95% CI: 1.02– 1.96), respectively.Conclusion: The prevalence of PreDM and MetS was relatively high in seemingly healthy persons. Distinct PreDM subgroups with or without MetS exhibited diverse clinical and biochemical features suggesting dissimilar pathogenesis.Keywords: seemingly healthy persons, health check-up clinic, prediabetes, metabolic syndrome

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