Recent changes in Clostridium difficile infection

Einstein (São Paulo). 2012;10(1):105-109


Journal Homepage

Journal Title: Einstein (São Paulo)

ISSN: 1679-4508 (Print); 2317-6385 (Online)

Publisher: Instituto Israelita de Ensino e Pesquisa Albert Einstein

Society/Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein

LCC Subject Category: Medicine

Country of publisher: Brazil

Language of fulltext: English, Portuguese

Full-text formats available: PDF, HTML, XML



Moacyr Silva Júnior


Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 38 weeks


Abstract | Full Text

Clostridium difficile is the main cause of nosocomial diarrhea. Diarrhea associated with C. difficile has increased incidence, morbidity, and mortality in the last few years. The major related risk factors include use of antibiotics, elderly patients and prolonged hospital stay. Many patients receive combinations of antibiotics or multiple antibiotics, which represents the main risk to develop diarrhea associated to C. difficile or its recurrence. Therefore, interventions to improve antibiotic prescribing, as well as compliance with infection control measures can reduce hospital-acquired C. difficile infections. This review addresses the epidemiological changes in C. difficile disease and its treatment.