Nature Communications (Feb 2020)
Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus
- Xiang-Ming Wang,
- Yang Lu,
- Yi-Meng Song,
- Jun Dong,
- Ruo-Yan Li,
- Guo-Liang Wang,
- Xu Wang,
- Shu-Dong Zhang,
- Zhou-Huan Dong,
- Min Lu,
- Shi-Yu Wang,
- Li-Yuan Ge,
- Guang-Da Luo,
- Run-Zhuo Ma,
- Steve George Rozen,
- Fan Bai,
- Di Wu,
- Lu-Lin Ma
Affiliations
- Xiang-Ming Wang
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Yang Lu
- Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases
- Yi-Meng Song
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Jun Dong
- Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases
- Ruo-Yan Li
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Guo-Liang Wang
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Xu Wang
- Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases
- Shu-Dong Zhang
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Zhou-Huan Dong
- Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases
- Min Lu
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Shi-Yu Wang
- Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases
- Li-Yuan Ge
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Guang-Da Luo
- Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases
- Run-Zhuo Ma
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Steve George Rozen
- Centre for Computational Biology, Duke-NUS Medical School
- Fan Bai
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- Di Wu
- Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases
- Lu-Lin Ma
- Biomedical Pioneering Innovation Center (BIOPIC) & Department of Urology, School of Life Sciences, Third Hospital, Peking University
- DOI
- https://doi.org/10.1038/s41467-020-14601-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The genomic heterogeneity of clear cell renal cell carcinoma (ccRCC) across populations is poorly understood. Here, the authors analyse a cohort of Chinese ccRCC cases revealing a mutational signature associated with aristolochic acid exposure, and higher mutational burden and enrichment for BAP1 and SETD2 mutations in ccRCC cases associated with tumor thrombus.
