Nature Communications (Oct 2017)
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
- Takaaki Akaike,
- Tomoaki Ida,
- Fan-Yan Wei,
- Motohiro Nishida,
- Yoshito Kumagai,
- Md. Morshedul Alam,
- Hideshi Ihara,
- Tomohiro Sawa,
- Tetsuro Matsunaga,
- Shingo Kasamatsu,
- Akiyuki Nishimura,
- Masanobu Morita,
- Kazuhito Tomizawa,
- Akira Nishimura,
- Satoshi Watanabe,
- Kenji Inaba,
- Hiroshi Shima,
- Nobuhiro Tanuma,
- Minkyung Jung,
- Shigemoto Fujii,
- Yasuo Watanabe,
- Masaki Ohmuraya,
- Péter Nagy,
- Martin Feelisch,
- Jon M. Fukuto,
- Hozumi Motohashi
Affiliations
- Takaaki Akaike
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Tomoaki Ida
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Fan-Yan Wei
- Department of Molecular Physiology, Graduate School of Medical Sciences, Kumamoto University
- Motohiro Nishida
- Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences
- Yoshito Kumagai
- Environmental Biology Section, Faculty of Medicine, University of Tsukuba
- Md. Morshedul Alam
- Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University
- Hideshi Ihara
- Department of Biological Science, Graduate School of Science, Osaka Prefecture University
- Tomohiro Sawa
- Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University
- Tetsuro Matsunaga
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Shingo Kasamatsu
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Akiyuki Nishimura
- Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences
- Masanobu Morita
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Kazuhito Tomizawa
- Department of Molecular Physiology, Graduate School of Medical Sciences, Kumamoto University
- Akira Nishimura
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Satoshi Watanabe
- Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
- Kenji Inaba
- Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
- Hiroshi Shima
- Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute
- Nobuhiro Tanuma
- Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute
- Minkyung Jung
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Shigemoto Fujii
- Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine
- Yasuo Watanabe
- Laboratory of Pharmacology, Showa Pharmaceutical University
- Masaki Ohmuraya
- Department of Genetics, Hyogo College of Medicine, Nishinomiya
- Péter Nagy
- Department of Molecular Immunology and Toxicology, National Institute of Oncology
- Martin Feelisch
- Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital and Institute for Life Sciences
- Jon M. Fukuto
- Department of Chemistry, Sonoma State University
- Hozumi Motohashi
- Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University
- DOI
- https://doi.org/10.1038/s41467-017-01311-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation.
