Serum metabonomics revealed the mechanism of Ganoderma amboinense polysaccharides in preventing non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet

Fei Ren; Qianping Chen; Chen Meng; Haiming Chen; Yongjie Zhou; Hao Zhang; Weijun Chen

Journal of Functional Foods (Jul 2021)

Serum metabonomics revealed the mechanism of Ganoderma amboinense polysaccharides in preventing non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet

Fei Ren,
Qianping Chen,
Chen Meng,
Haiming Chen,
Yongjie Zhou,
Hao Zhang,
Weijun Chen

Affiliations

Fei Ren: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China
Qianping Chen: School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China
Chen Meng: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China
Haiming Chen: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China; Huachuang Institute of Areca Research-Hainan, 88 People Road, Haikou 570208, PR China; Corresponding authors at: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China.
Yongjie Zhou: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China
Hao Zhang: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China
Weijun Chen: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China; Chunguang Agro-product Processing Institute, Wenchang 571333, China; Corresponding authors at: Key Laboratory of Food Nutrition and Functional Food of Hainan Province of China, Hainan University, 58 People Road, Haikou 570228, PR China.

Journal volume & issue: Vol. 82
p. 104496

Abstract

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Non-alcoholic fatty liver disease (NAFLD) is one of the most widespread chronic diseases. Previous reports showed that Ganoderma amboinense polysaccharide (GAP) could protect the liver. In this study, high-fat diet (HFD) mice were given GAP for 8 weeks to evaluate the feasibility of GAP to prevent NAFLD and explore its mechanism of action. The results showed that GAP effectively prevented the development of NAFLD, at the same time, reduced the body weight, liver weight and blood lipid levels. Through the serum biochemical analysis and metabolomics analysis, it was found that GAP promoted fat transport in the liver by regulating the phosphatidylcholine content in the blood. At the same time, GAP regulated some metabolic pathways and protected the mitochondrial function of HFD-mouse liver cells, which is the basis for the rapid catabolism of lipids. These results indicated that GAP could be used as a potential preventive and therapeutic agent for NAFLD.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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