Nature Communications (Jan 2018)

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

  • Mark A. T. Blaskovich,
  • Karl A. Hansford,
  • Yujing Gong,
  • Mark S. Butler,
  • Craig Muldoon,
  • Johnny X. Huang,
  • Soumya Ramu,
  • Alberto B. Silva,
  • Mu Cheng,
  • Angela M. Kavanagh,
  • Zyta Ziora,
  • Rajaratnam Premraj,
  • Fredrik Lindahl,
  • Tanya A. Bradford,
  • June C. Lee,
  • Tomislav Karoli,
  • Ruby Pelingon,
  • David J. Edwards,
  • Maite Amado,
  • Alysha G. Elliott,
  • Wanida Phetsang,
  • Noor Huda Daud,
  • Johan E. Deecke,
  • Hanna E. Sidjabat,
  • Sefetogi Ramaologa,
  • Johannes Zuegg,
  • Jason R. Betley,
  • Andrew P. G. Beevers,
  • Richard A. G. Smith,
  • Jason A. Roberts,
  • David L. Paterson,
  • Matthew A. Cooper

DOI
https://doi.org/10.1038/s41467-017-02123-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

Read online

The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in vivo activities against glycopeptide-resistant strains.