Nature Communications (Jan 2018)
Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
- Mark A. T. Blaskovich,
- Karl A. Hansford,
- Yujing Gong,
- Mark S. Butler,
- Craig Muldoon,
- Johnny X. Huang,
- Soumya Ramu,
- Alberto B. Silva,
- Mu Cheng,
- Angela M. Kavanagh,
- Zyta Ziora,
- Rajaratnam Premraj,
- Fredrik Lindahl,
- Tanya A. Bradford,
- June C. Lee,
- Tomislav Karoli,
- Ruby Pelingon,
- David J. Edwards,
- Maite Amado,
- Alysha G. Elliott,
- Wanida Phetsang,
- Noor Huda Daud,
- Johan E. Deecke,
- Hanna E. Sidjabat,
- Sefetogi Ramaologa,
- Johannes Zuegg,
- Jason R. Betley,
- Andrew P. G. Beevers,
- Richard A. G. Smith,
- Jason A. Roberts,
- David L. Paterson,
- Matthew A. Cooper
Affiliations
- Mark A. T. Blaskovich
- Institute for Molecular Bioscience, The University of Queensland
- Karl A. Hansford
- Institute for Molecular Bioscience, The University of Queensland
- Yujing Gong
- Institute for Molecular Bioscience, The University of Queensland
- Mark S. Butler
- Institute for Molecular Bioscience, The University of Queensland
- Craig Muldoon
- Institute for Molecular Bioscience, The University of Queensland
- Johnny X. Huang
- Institute for Molecular Bioscience, The University of Queensland
- Soumya Ramu
- Institute for Molecular Bioscience, The University of Queensland
- Alberto B. Silva
- Institute for Molecular Bioscience, The University of Queensland
- Mu Cheng
- Institute for Molecular Bioscience, The University of Queensland
- Angela M. Kavanagh
- Institute for Molecular Bioscience, The University of Queensland
- Zyta Ziora
- Institute for Molecular Bioscience, The University of Queensland
- Rajaratnam Premraj
- Institute for Molecular Bioscience, The University of Queensland
- Fredrik Lindahl
- Institute for Molecular Bioscience, The University of Queensland
- Tanya A. Bradford
- Institute for Molecular Bioscience, The University of Queensland
- June C. Lee
- Institute for Molecular Bioscience, The University of Queensland
- Tomislav Karoli
- Institute for Molecular Bioscience, The University of Queensland
- Ruby Pelingon
- Institute for Molecular Bioscience, The University of Queensland
- David J. Edwards
- Institute for Molecular Bioscience, The University of Queensland
- Maite Amado
- Institute for Molecular Bioscience, The University of Queensland
- Alysha G. Elliott
- Institute for Molecular Bioscience, The University of Queensland
- Wanida Phetsang
- Institute for Molecular Bioscience, The University of Queensland
- Noor Huda Daud
- Institute for Molecular Bioscience, The University of Queensland
- Johan E. Deecke
- Institute for Molecular Bioscience, The University of Queensland
- Hanna E. Sidjabat
- UQ Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women’s Hospital Campus
- Sefetogi Ramaologa
- Institute for Molecular Bioscience, The University of Queensland
- Johannes Zuegg
- Institute for Molecular Bioscience, The University of Queensland
- Jason R. Betley
- AdProTech Ltd, Chesterford Research Park
- Andrew P. G. Beevers
- AdProTech Ltd, Chesterford Research Park
- Richard A. G. Smith
- AdProTech Ltd, Chesterford Research Park
- Jason A. Roberts
- UQ Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women’s Hospital Campus
- David L. Paterson
- UQ Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women’s Hospital Campus
- Matthew A. Cooper
- Institute for Molecular Bioscience, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-017-02123-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in vivo activities against glycopeptide-resistant strains.
