Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

Fauziyya Muhammad; Priscilla N. Avalos; M. H. Mursalin; Jian-Xing Ma; Michelle C. Callegan; Michelle C. Callegan; Michelle C. Callegan; Darren J. Lee; Darren J. Lee; Darren J. Lee

doi:10.3389/fimmu.2020.00975

Frontiers in Immunology (May 2020)

Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells

Fauziyya Muhammad,
Priscilla N. Avalos,
M. H. Mursalin,
Jian-Xing Ma,
Michelle C. Callegan,
Michelle C. Callegan,
Michelle C. Callegan,
Darren J. Lee,
Darren J. Lee,
Darren J. Lee

Affiliations

Fauziyya Muhammad: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Priscilla N. Avalos: Department of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
M. H. Mursalin: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Jian-Xing Ma: Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Michelle C. Callegan: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Michelle C. Callegan: Department of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Michelle C. Callegan: Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Darren J. Lee: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Darren J. Lee: Department of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
Darren J. Lee: Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

DOI: https://doi.org/10.3389/fimmu.2020.00975
Journal volume & issue: Vol. 11

Abstract

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Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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