YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Antonio Totaro; Martina Castellan; Giusy Battilana; Francesca Zanconato; Luca Azzolin; Stefano Giulitti; Michelangelo Cordenonsi; Stefano Piccolo

doi:10.1038/ncomms15206

Nature Communications (May 2017)

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Antonio Totaro,
Martina Castellan,
Giusy Battilana,
Francesca Zanconato,
Luca Azzolin,
Stefano Giulitti,
Michelangelo Cordenonsi,
Stefano Piccolo

Affiliations

Antonio Totaro: Department of Molecular Medicine (DMM), University of Padua School of Medicine
Martina Castellan: Department of Molecular Medicine (DMM), University of Padua School of Medicine
Giusy Battilana: Department of Molecular Medicine (DMM), University of Padua School of Medicine
Francesca Zanconato: Department of Molecular Medicine (DMM), University of Padua School of Medicine
Luca Azzolin: Department of Molecular Medicine (DMM), University of Padua School of Medicine
Stefano Giulitti: Department of Molecular Medicine (DMM), University of Padua School of Medicine
Michelangelo Cordenonsi: Department of Molecular Medicine (DMM), University of Padua School of Medicine
Stefano Piccolo: Department of Molecular Medicine (DMM), University of Padua School of Medicine

DOI: https://doi.org/10.1038/ncomms15206
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Notch signalling is a fundamental negative regulator of epidermal stemness. Here, the authors show that cell mechanics through YAP/TAZ activity prevent primary human keratinocytes from differentiating by inhibiting cell-autonomous Notch signals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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