Molecules (Jun 2014)

Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative

  • Gaspar Diaz,
  • Michelle A. A. de Freitas,
  • Maria E. Ricci-Silva,
  • Marisa A. N. Diaz

DOI
https://doi.org/10.3390/molecules19067429
Journal volume & issue
Vol. 19, no. 6
pp. 7429 – 7439

Abstract

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An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.

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