PLoS ONE (Jan 2024)

Sex as a risk factor regarding presbyopia in the rhesus monkey.

  • Mary Ann Croft,
  • Jared P Mcdonald,
  • Julie Kiland,
  • Julie A Mattison,
  • George S Roth,
  • Don Ingram,
  • Paul L Kaufman

DOI
https://doi.org/10.1371/journal.pone.0300476
Journal volume & issue
Vol. 19, no. 4
p. e0300476

Abstract

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PurposeTo determine the effect of sex as a risk factor regarding presbyopia.MethodsMaximum accommodation was pharmacologically induced (40% cabachol corneal iontophoresis) in 97 rhesus monkeys (49 males and 48 females) ranging in age from 8 to 36 years old. Accommodation was measured by Hartinger coincidence refractometry.ResultsAccommodative amplitude measured refractometrically decreased with age, and the rate of change was not different between males and females (p = 0.827).ConclusionsPresbyopia is essentially sex neutral, and no one is spared. There may be modest variations between different populations for various reasons, but essentially it is monotonously predictable. At present there is no biological therapeutic.