Nature Communications (Nov 2017)
Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
- Benjamin J. Burwitz,
- Helen L. Wu,
- Shaheed Abdulhaqq,
- Christine Shriver-Munsch,
- Tonya Swanson,
- Alfred W. Legasse,
- Katherine B. Hammond,
- Stephanie L. Junell,
- Jason S. Reed,
- Benjamin N. Bimber,
- Justin M. Greene,
- Gabriela M. Webb,
- Mina Northrup,
- Wolfram Laub,
- Paul Kievit,
- Rhonda MacAllister,
- Michael K. Axthelm,
- Rebecca Ducore,
- Anne Lewis,
- Lois M. A. Colgin,
- Theodore Hobbs,
- Lauren D. Martin,
- Betsy Ferguson,
- Charles R. Thomas Jr.,
- Angela Panoskaltsis-Mortari,
- Gabrielle Meyers,
- Jeffrey J. Stanton,
- Richard T. Maziarz,
- Jonah B. Sacha
Affiliations
- Benjamin J. Burwitz
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Helen L. Wu
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Shaheed Abdulhaqq
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Christine Shriver-Munsch
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Tonya Swanson
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Alfred W. Legasse
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Katherine B. Hammond
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Stephanie L. Junell
- Division of Medical Physics, Department of Radiation Medicine, Oregon Health & Science University
- Jason S. Reed
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Benjamin N. Bimber
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Justin M. Greene
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Gabriela M. Webb
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Mina Northrup
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Wolfram Laub
- Division of Medical Physics, Department of Radiation Medicine, Oregon Health & Science University
- Paul Kievit
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Rhonda MacAllister
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Michael K. Axthelm
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- Rebecca Ducore
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Anne Lewis
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Lois M. A. Colgin
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Theodore Hobbs
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Lauren D. Martin
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Betsy Ferguson
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Charles R. Thomas Jr.
- Division of Medical Physics, Department of Radiation Medicine, Oregon Health & Science University
- Angela Panoskaltsis-Mortari
- Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota
- Gabrielle Meyers
- Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University
- Jeffrey J. Stanton
- Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue
- Richard T. Maziarz
- Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University
- Jonah B. Sacha
- Vaccine and Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Avenue
- DOI
- https://doi.org/10.1038/s41467-017-01631-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Rhesus macaques are not ideal for studying response to allogeneic hematopoietic stem cell transplant (allo-HSCT) owing to complex MHC genetics that prevent full MHC-matching. Here the authors show that inbred Mauritian-origin cynomolgus macaques are a superior preclinical model of allogeneic stem cell transplantation that mimics diverse clinical outcomes of human allo-HSCT.
