Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Dalong Ni; Dawei Jiang; Christopher J. Kutyreff; Jianhao Lai; Yongjun Yan; Todd E. Barnhart; Bo Yu; Hyung-Jun Im; Lei Kang; Steve Y. Cho; Zhaofei Liu; Peng Huang; Jonathan W. Engle; Weibo Cai

doi:10.1038/s41467-018-07890-8

Nature Communications (Dec 2018)

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Dalong Ni,
Dawei Jiang,
Christopher J. Kutyreff,
Jianhao Lai,
Yongjun Yan,
Todd E. Barnhart,
Bo Yu,
Hyung-Jun Im,
Lei Kang,
Steve Y. Cho,
Zhaofei Liu,
Peng Huang,
Jonathan W. Engle,
Weibo Cai

Affiliations

Dalong Ni: Departments of Radiology and Medical Physics, University of Wisconsin
Dawei Jiang: Departments of Radiology and Medical Physics, University of Wisconsin
Christopher J. Kutyreff: Departments of Radiology and Medical Physics, University of Wisconsin
Jianhao Lai: Departments of Radiology and Medical Physics, University of Wisconsin
Yongjun Yan: Departments of Radiology and Medical Physics, University of Wisconsin
Todd E. Barnhart: Departments of Radiology and Medical Physics, University of Wisconsin
Bo Yu: Departments of Radiology and Medical Physics, University of Wisconsin
Hyung-Jun Im: Departments of Radiology and Medical Physics, University of Wisconsin
Lei Kang: Departments of Radiology and Medical Physics, University of Wisconsin
Steve Y. Cho: Departments of Radiology and Medical Physics, University of Wisconsin
Zhaofei Liu: Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center
Peng Huang: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University
Jonathan W. Engle: Departments of Radiology and Medical Physics, University of Wisconsin
Weibo Cai: Departments of Radiology and Medical Physics, University of Wisconsin

DOI: https://doi.org/10.1038/s41467-018-07890-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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There are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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