Anais Brasileiros de Dermatologia (Aug 2013)

Pulse therapy in pemphigus: report of 11 cases

  • Nurimar Conceicao Fernandes,
  • Mariana Menezes

DOI
https://doi.org/10.1590/abd1806-4841.20131840
Journal volume & issue
Vol. 88, no. 4
pp. 672 – 675

Abstract

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In this study, five cases of pemphigus vulgaris and two cases of pemphigus foliaceus were treated with cyclophosphamide pulse therapy associated with prednisone, resulting in the need for a smaller maintenance dose of prednisone. In three cases of pemphigus vulgaris and one case of pemphigus foliaceus, dexamethasone and cyclophosphamide pulse therapy associated with prednisone helped the lesions to heal more rapidly. Neither treatment however prevented the recurrence of the disease. Amenorrhea, myelotoxicity and Stevens-Johnson syndrome were among the cyclophosphamide side effects. All the patients treated with prednisone experienced known side effects.

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