Вопросы современной педиатрии (Jan 2010)

CYSTATIN S AS A MARKER OF CYCLOSPORINE A RENAL TOXICITY IN CHILDREN WITH NEPHROTIC SYNDROME

  • O.V. Komarova,
  • M.V. Rozhkova,
  • A.N. Tsygin,
  • A.G. Kucherenko,
  • I.E. Smirnov,
  • L.V. Leonova

Journal volume & issue
Vol. 9, no. 1
pp. 131 – 135

Abstract

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The use of cystatin С as a probable marker of renal toxicity of cyclosporine A in children with nephritic syndrome, treated with this medication for a long time, is the subject of an interest. The present study included 29 children treated with cyclosporine A, divided into 3 groups depending on the duration of treatment (< 1 year, 1–2 years and > 2 years). The increase of cystatin С level in these groups compared with cystatin С level in control group (10 children without diseases of kidney) was marked. The highest level of cystatin С was detected in children treated with therapeutic doses of cyclosporine A (3–5 mg/kg daily) over 1 year. Authors showed positive correlation between cystatin С level in serum and medication’s dose.Key words: children, nephritic syndrome, cystatin С, cyclosporine A.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(1):131-135)