Frontiers in Endocrinology (Nov 2021)

Association of Glycosylated Hemoglobin A1c Level With Sudden Sensorineural Hearing Loss: A Prospective Study

  • Ying Shen,
  • Ying Shen,
  • Zhong Zheng,
  • Zhong Zheng,
  • Lili Xiao,
  • Lili Xiao,
  • Chengqi Liu,
  • Chengqi Liu,
  • Jingyi Guo,
  • Zhengnong Chen,
  • Zhengnong Chen,
  • Yaqin Wu,
  • Yaqin Wu,
  • Haibo Shi,
  • Haibo Shi,
  • Zhen Zhang,
  • Zhen Zhang,
  • Di Qian,
  • Yanmei Feng,
  • Yanmei Feng,
  • Shankai Yin,
  • Shankai Yin

DOI
https://doi.org/10.3389/fendo.2021.763021
Journal volume & issue
Vol. 12

Abstract

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Glycosylated hemoglobin A1c (HbA1c) level has strong relevance to microvascular disorders, which are also thought to be the current main aspect of sudden sensorineural hearing loss (SSNHL), so we aim to elucidate the association of the HbA1c level with the severity, types, and prognosis of SSNHL. In this study, comparative analyses based on propensity score matching of the severity, types, and prognosis of SSNHL with the HbA1c level in 116 patients diagnosed as SSNHL were conducted, where they were divided into diabetes mellitus (DM) group and non-DM group. We finally found that, among patients with SSNHL, diabetic patients had a higher HbA1c level, more severe hearing loss, and poorer prognosis than non-diabetic patients. The HbA1c level was found to be significantly correlated with the severity and types of SSNHL, while no strong relevance was found between the higher HbA1c level and the poorer prognosis of SSNHL.

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