Piperidin—Thiosemicarbazone hybrid structures: Spectral characterization, anti-inflammatory activity and docking studies

V.J. Ramya Devi; G. Vallal Perumal; G. Rajarajan; K. Sivakumar; V. Thanikachalam

Chemical Physics Impact (Jun 2024)

Piperidin—Thiosemicarbazone hybrid structures: Spectral characterization, anti-inflammatory activity and docking studies

V.J. Ramya Devi,
G. Vallal Perumal,
G. Rajarajan,
K. Sivakumar,
V. Thanikachalam

Affiliations

V.J. Ramya Devi: Department of Chemistry, Annamalai University, Annamalainagar 608002, India
G. Vallal Perumal: Department of Chemistry, Annamalai University, Annamalainagar 608002, India
G. Rajarajan: Department of Chemistry, Annamalai University, Annamalainagar 608002, India; Department of Chemistry, Bharathiar University, Coimbatore 641046, India; Corresponding author at: Department of Chemistry, Annamalai University, Annamalainagar 608002, India.
K. Sivakumar: Department of Chemistry, Faculty of Science, Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya (Deemed to be University), Enathur, Kanchipuram 631 561, Tamilnadu, India
V. Thanikachalam: Department of Chemistry, Annamalai University, Annamalainagar 608002, India

Journal volume & issue: Vol. 8
p. 100504

Abstract

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In this paper, hybrid structure of piperidin—thiosemicarbazone with different substituents; R = −H, −F, −OCH3, −Cl, −NO2 (compounds 1–5) are reported. Structure of synthesized compounds 1–5 were elucidated using spectral characterization. Upon testing the synthesized hybrid structures for anti-inflammatory activity, the compounds exhibited significant effect.

Published in Chemical Physics Impact

ISSN: 2667-0224 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physics; Science: Chemistry
Website: https://www.journals.elsevier.com/chemical-physics-impact/

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