Nature Communications (Nov 2022)

Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice

  • Diana Rodrigues,
  • Luis Jacinto,
  • Margarida Falcão,
  • Ana Carolina Castro,
  • Alexandra Cruz,
  • Cátia Santa,
  • Bruno Manadas,
  • Fernanda Marques,
  • Nuno Sousa,
  • Patricia Monteiro

DOI
https://doi.org/10.1038/s41467-022-35028-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Chronic stress can trigger or worsen motor symptoms in neuropsychiatric disorders. Here, the authors show that SOM interneurons in the striatum are involved in stress-induced motor behaviors.