Case Reports in Oncology (May 2013)

Pancreatic Metastasis from Mixed Adenoneuroendocrine Carcinoma of the Uterine Cervix: A Case Report

  • Chihiro Nishimura,
  • Hideaki Naoe,
  • Shunpei Hashigo,
  • Hideharu Tsutsumi,
  • Shotaro Ishii,
  • Takeyasu Konoe,
  • Takehisa Watanabe,
  • Takashi Shono,
  • Kouichi Sakurai,
  • Kiyomi Takaishi,
  • Yoshiaki Ikuta,
  • Akira Chikamoto,
  • Motohiko Tanaka,
  • Ken-ichi Iyama,
  • Hideo Baba,
  • Hidetaka Katabuchi,
  • Yutaka Sasaki

DOI
https://doi.org/10.1159/000351308
Journal volume & issue
Vol. 6, no. 2
pp. 256 – 262

Abstract

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Metastatic cancers of the pancreas are rare, accounting for approximately 2-4% of all pancreatic malignancies. Renal cell carcinoma is the most common solid tumor that metastasizes to the pancreas. Here, we present a case of uterine cervical carcinoma metastasizing to the pancreas and review the literature regarding this rare event. A 44-year-old woman with a uterine cervical tumor had undergone radical hysterectomy and had been diagnosed pathologically with stage Ib mixed adenoneuroendocrine carcinoma in 2004. She underwent concurrent radiotherapy and chemotherapy postoperatively. Pulmonary metastases subsequently appeared in 2008 and 2011, and she underwent complete resection of the lung tumors by video-assisted thoracic surgery. Although she was followed up without any treatment and with no other recurrences, positron emission tomography revealed an area of abnormal uptake within the pancreatic body in 2012. Enhanced computed tomography demonstrated a 20-mm lesion in the pancreatic body and upstream pancreatic duct dilatation. Endoscopic ultrasonography-guided fine needle aspiration was performed and pathological examination suggested neuroendocrine carcinoma (NEC). On the basis of these results and the patient's oncological background, lesions in the pancreatic body were diagnosed as secondary metastasis from the cervical carcinoma that had been treated 8 years earlier. No other distant metastases were visualized, and the patient subsequently underwent middle pancreatectomy. Pathological examination showed NEC consistent with pancreatic metastasis from the uterine cervical carcinoma. The patient has survived 7 months since the middle pancreatectomy without any signs of local recurrence or other metastatic lesions.

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