Associations between gestational diabetes mellitus and the neurodevelopment of offspring from 1 month to 72 months: study protocol for a cohort study
Bin Peng,
Ping Zhou,
Chao Li,
Ting Yang,
Li Chen,
Jie Chen,
Hong Peng,
Yue Zhang,
Yixi Cai,
Yongfang Liu,
Yinying Li,
Yirong Hu,
Yajun Fu,
Zhenming Wang,
Tingyu Li
Affiliations
Bin Peng
School of Public Health and Management, Department of Health Statistics, Chongqing Medical University, Chongqing, People’s Republic of China
Ping Zhou
1 Institute for Emergency and Disaster Medicine, Sichuan Academy of Medical Science, Sichuan Provincial People`s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Chao Li
3 School of Physical Education, Qingdao University, Qingdao, Shandong, China
Ting Yang
1 Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China
Li Chen
1 Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Jie Chen
Department of Critical Care Medicine, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China
Hong Peng
2 Beijing Shijitan Hospital, Capital Medical University, Beijing, China
Yue Zhang
Department of Child Care, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China
Yixi Cai
Department of Child Care, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China
Yongfang Liu
Division of Clinical Nutrition, Children’s Hospital of Chongqing Medical University, Chongqing, China
Yinying Li
Department of Child Care, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China
Yirong Hu
Department of Outpatient, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China
Yajun Fu
Department of Obstetrics, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China
Zhenming Wang
Department of Obstetrics, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, China
Tingyu Li
Division of Growth, Development and Mental health of Children and Adolescence, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
Introduction Gestational diabetes mellitus (GDM) is a common gestational disease and an important global public health problem. GDM may affect the short-term and long-term health of offspring, but the associations between GDM and the neurodevelopment of offspring of mothers with GDM (OGDM) are still unclear, and studies based on the Chinese population are lacking. We aim to determine the associations between GDM and the neurodevelopment of OGDM by studying a cohort of OGDM and offspring of non-GDM mothers.Methods and analysis The single-centre prospective cohort study is being conducted in China over 7 years. A total of 490 OGDM (GDM group) and 490 fromof healthy mothers (control group) will be enrolled during the same period. Baseline characteristics, neuropsychological development scores and clinical data at specific time points (at 0, 1, 3, 6, 12, 24, 36, 48, 60 and 72 months old) will be collected from the children in both groups until the age of 6 years. The associations between GDM and the neurodevelopment of OGDM from infancy to preschool age will be analysed using a multiple linear regression model adjusted for confounders. In addition, we will compare longitudinal data to further assess the effects of GDM on neurodevelopmental trajectories.Ethics and dissemination The study has been approved by the Ethics Committee of the Children’s Hospital of Chongqing Medical University (Approval Number: (2019) Institutional Review Board (IRB) (STUDY) No. 85). The findings of this study will be disseminated through open access journals, peer-reviewed journals and scientific meetings.Trial registration number NCT03997396.
