Nature Communications (Sep 2022)
Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy
- Michelle L. Korir,
- Ryan S. Doster,
- Jacky Lu,
- Miriam A. Guevara,
- Sabrina K. Spicer,
- Rebecca E. Moore,
- Jamisha D. Francis,
- Lisa M. Rogers,
- Kathryn P. Haley,
- Amondrea Blackman,
- Kristen N. Noble,
- Alison J. Eastman,
- Janice A. Williams,
- Steven M. Damo,
- Kelli L. Boyd,
- Steven D. Townsend,
- C. Henrique Serezani,
- David M. Aronoff,
- Shannon D. Manning,
- Jennifer A. Gaddy
Affiliations
- Michelle L. Korir
- Michigan State University, Department of Microbiology and Molecular Genetics
- Ryan S. Doster
- Department of Medicine, Vanderbilt University Medical Center
- Jacky Lu
- Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
- Miriam A. Guevara
- Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
- Sabrina K. Spicer
- Department of Chemistry, Vanderbilt University
- Rebecca E. Moore
- Department of Medicine, Vanderbilt University Medical Center
- Jamisha D. Francis
- Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
- Lisa M. Rogers
- Department of Medicine, Vanderbilt University Medical Center
- Kathryn P. Haley
- Department of Medicine, Vanderbilt University Medical Center
- Amondrea Blackman
- Department of Medicine, Vanderbilt University Medical Center
- Kristen N. Noble
- Department of Medicine, Vanderbilt University Medical Center
- Alison J. Eastman
- Department of Medicine, Vanderbilt University Medical Center
- Janice A. Williams
- United States Army Medical Research Institute of Infectious Diseases
- Steven M. Damo
- Department of Life and Physical Sciences, Fisk University
- Kelli L. Boyd
- Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
- Steven D. Townsend
- Department of Chemistry, Vanderbilt University
- C. Henrique Serezani
- Department of Medicine, Vanderbilt University Medical Center
- David M. Aronoff
- Department of Medicine, Vanderbilt University Medical Center
- Shannon D. Manning
- Michigan State University, Department of Microbiology and Molecular Genetics
- Jennifer A. Gaddy
- Department of Medicine, Vanderbilt University Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-32916-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Perinatal infection with Group B Streptococcus (GBS) is associated with preterm birth, neonatal sepsis, and stillbirth. Here, Korir et al. show that gene cadD, encoding a putative metal efflux transporter, is important for metal detoxification, immune evasion and bacterial proliferation in the pregnant host.
