STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing

Kana Aoki; Shota Harada; Keita Kawaji; Kenji Matsuzawa; Seiichi Uchida; Junichi Ikenouchi

doi:10.1038/s41467-020-20826-5

Nature Communications (Jan 2021)

STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing

Kana Aoki,
Shota Harada,
Keita Kawaji,
Kenji Matsuzawa,
Seiichi Uchida,
Junichi Ikenouchi

Affiliations

Kana Aoki: Department of Biology, Faculty of Sciences, Kyushu University
Shota Harada: Department of Advanced Information Technology, Kyushu University
Keita Kawaji: Department of Advanced Information Technology, Kyushu University
Kenji Matsuzawa: Department of Biology, Faculty of Sciences, Kyushu University
Seiichi Uchida: Department of Advanced Information Technology, Kyushu University
Junichi Ikenouchi: Department of Biology, Faculty of Sciences, Kyushu University

DOI: https://doi.org/10.1038/s41467-020-20826-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The cytoplasm in mammalian cells is considered homogeneous. Here authors report that the cytoplasmic fluidity is regulated in the blebbing cells, which is regulated by calcium concentration in the expanding blebs and involves the STIM-Orai1 pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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