Generation of stem cell-derived β-cells from patients with type 1 diabetes

Jeffrey R. Millman; Chunhui Xie; Alana Van Dervort; Mads Gürtler; Felicia W. Pagliuca; Douglas A. Melton

doi:10.1038/ncomms11463

Nature Communications (May 2016)

Generation of stem cell-derived β-cells from patients with type 1 diabetes

Jeffrey R. Millman,
Chunhui Xie,
Alana Van Dervort,
Mads Gürtler,
Felicia W. Pagliuca,
Douglas A. Melton

Affiliations

Jeffrey R. Millman: Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Chunhui Xie: Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University
Alana Van Dervort: Case Western Reserve University School of Medicine
Mads Gürtler: Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University
Felicia W. Pagliuca: Semma Therapeutics, Inc.
Douglas A. Melton: Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University

DOI: https://doi.org/10.1038/ncomms11463
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

Read online

Pancreatic β cells can be generated from pluripotent stem cells. Here, the authors show that human induced pluripotent stem cells from patients with type 1 diabetes can be differentiated into β-like cells that have no detectable differences compared with cells from non-diabetic individuals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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