Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase

Kenichiro Matsuzaki; Shizuka Kondo; Tatsuya Ishikawa; Akira Shinohara

doi:10.1038/s41467-019-09190-1

Nature Communications (Mar 2019)

Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase

Kenichiro Matsuzaki,
Shizuka Kondo,
Tatsuya Ishikawa,
Akira Shinohara

Affiliations

Kenichiro Matsuzaki: Laboratory of Genome and Chromosome Functions, Institute for Protein Research, Osaka University
Shizuka Kondo: Laboratory of Genome and Chromosome Functions, Institute for Protein Research, Osaka University
Tatsuya Ishikawa: Laboratory of Genome and Chromosome Functions, Institute for Protein Research, Osaka University
Akira Shinohara: Laboratory of Genome and Chromosome Functions, Institute for Protein Research, Osaka University

DOI: https://doi.org/10.1038/s41467-019-09190-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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RAD51 assembly on single-stranded DNAs is an important step in the homology-dependent repair of DNA damage. Here authors reveal a role for the human RAD51 paralogue, SWSAP1, as a regulator of RAD51 assembly, by antagonizing RAD51 remodeller, FIGNL1 AAA + ATPase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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