YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

Dan Wang; Yening Zhang; Xueming Xu; Jianfeng Wu; Yue Peng; Jing Li; Ruiheng Luo; Lingmin Huang; Liping Liu; Songlin Yu; Ningjie Zhang; Ben Lu; Kai Zhao

doi:10.1038/s41467-021-22987-3

Nature Communications (May 2021)

YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

Dan Wang,
Yening Zhang,
Xueming Xu,
Jianfeng Wu,
Yue Peng,
Jing Li,
Ruiheng Luo,
Lingmin Huang,
Liping Liu,
Songlin Yu,
Ningjie Zhang,
Ben Lu,
Kai Zhao

Affiliations

Dan Wang: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Yening Zhang: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Xueming Xu: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Jianfeng Wu: State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University
Yue Peng: Department of Critical Care Medicine, The Third Xiangya Hospital, Central South University
Jing Li: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Ruiheng Luo: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Lingmin Huang: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Liping Liu: Department of General Surgery, The Third Xiangya Hospital, Central South University
Songlin Yu: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Ningjie Zhang: Department of Blood Transfusion, The Second Xiangya Hospital, Central South University
Ben Lu: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University
Kai Zhao: Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The Third Xiangya Hospital, Central South University

DOI: https://doi.org/10.1038/s41467-021-22987-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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YAP is known to play a role both in organ size via the Hippo signalling pathway and in inflammation, though the precise mechanism are unclear. Here, the authors report that YAP promotes activation of the NLRP3 inflammosome through binding interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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