Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein

Jinkal Modi; Abhishek Roy; Anjan K. Pradhan; Amit Kumar; Sarmistha Talukdar; Praveen Bhoopathi; Santanu Maji; Padmanabhan Mannangatti; Daniel Sanchez De La Rosa; Jiong Li; Chunqing Guo; Mark A. Subler; Jolene J. Windle; Webster K. Cavenee; Devanand Sarkar; Xiang-Yang Wang; Swadesh K. Das; Luni Emdad; Paul B. Fisher

doi:10.3390/ijms23010072

International Journal of Molecular Sciences (Dec 2021)

Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein

Jinkal Modi,
Abhishek Roy,
Anjan K. Pradhan,
Amit Kumar,
Sarmistha Talukdar,
Praveen Bhoopathi,
Santanu Maji,
Padmanabhan Mannangatti,
Daniel Sanchez De La Rosa,
Jiong Li,
Chunqing Guo,
Mark A. Subler,
Jolene J. Windle,
Webster K. Cavenee,
Devanand Sarkar,
Xiang-Yang Wang,
Swadesh K. Das,
Luni Emdad,
Paul B. Fisher

Affiliations

Jinkal Modi: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Abhishek Roy: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Anjan K. Pradhan: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Amit Kumar: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Sarmistha Talukdar: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Praveen Bhoopathi: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Santanu Maji: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Padmanabhan Mannangatti: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Daniel Sanchez De La Rosa: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Jiong Li: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23218, USA
Chunqing Guo: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Mark A. Subler: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Jolene J. Windle: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Webster K. Cavenee: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92037, USA
Devanand Sarkar: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Xiang-Yang Wang: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Swadesh K. Das: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Luni Emdad: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA
Paul B. Fisher: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23218, USA

DOI: https://doi.org/10.3390/ijms23010072
Journal volume & issue: Vol. 23, no. 1
p. 72

Abstract

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Melanoma differentiation associated gene-7/interleukin-24 (MDA-7/IL-24), a secreted protein of the IL-10 family, was first identified more than two decades ago as a novel gene differentially expressed in terminally differentiating human metastatic melanoma cells. MDA-7/IL-24 functions as a potent tumor suppressor exerting a diverse array of functions including the inhibition of tumor growth, invasion, angiogenesis, and metastasis, and induction of potent “bystander” antitumor activity and synergy with conventional cancer therapeutics. MDA-7/IL-24 induces cancer-specific cell death through apoptosis or toxic autophagy, which was initially established in vitro and in preclinical animal models in vivo and later in a Phase I clinical trial in patients with advanced cancers. This review summarizes the history and our current understanding of the molecular/biological mechanisms of MDA-7/IL-24 action rendering it a potent cancer suppressor.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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