Frontiers in Genetics (May 2023)
A new perspective on Alzheimer’s disease: m6A modification
- Lei Xia,
- Lei Xia,
- Lei Xia,
- Fan Zhang,
- Fan Zhang,
- Fan Zhang,
- Fan Zhang,
- Fan Zhang,
- Yulu Li,
- Yulu Li,
- Yulu Li,
- Yuemi Mo,
- Yuemi Mo,
- Yuemi Mo,
- Lingqiu Zhang,
- Lingqiu Zhang,
- Lingqiu Zhang,
- Qianhua Li,
- Qianhua Li,
- Qianhua Li,
- Minghuang Luo,
- Minghuang Luo,
- Minghuang Luo,
- Xiaotao Hou,
- Xiaotao Hou,
- Xiaotao Hou,
- Xiaotao Hou,
- Zhengcai Du,
- Zhengcai Du,
- Zhengcai Du,
- Zhengcai Du,
- Jiagang Deng,
- Jiagang Deng,
- Jiagang Deng,
- Jiagang Deng,
- Erwei Hao,
- Erwei Hao,
- Erwei Hao,
- Erwei Hao
Affiliations
- Lei Xia
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Lei Xia
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Lei Xia
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Fan Zhang
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Fan Zhang
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Fan Zhang
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Fan Zhang
- Guangxi International Zhang Medicine Hospital Affiliated to Gungxi University of Chinese Medicine, Nanning, China
- Fan Zhang
- Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases, Guangxi University of Chinese Medicine, Nanning, China
- Yulu Li
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Yulu Li
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Yulu Li
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Yuemi Mo
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Yuemi Mo
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Yuemi Mo
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Lingqiu Zhang
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Lingqiu Zhang
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Lingqiu Zhang
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Qianhua Li
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Qianhua Li
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Qianhua Li
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Minghuang Luo
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Minghuang Luo
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Minghuang Luo
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Xiaotao Hou
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Xiaotao Hou
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Xiaotao Hou
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Xiaotao Hou
- Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases, Guangxi University of Chinese Medicine, Nanning, China
- Zhengcai Du
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Zhengcai Du
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Zhengcai Du
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Zhengcai Du
- Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases, Guangxi University of Chinese Medicine, Nanning, China
- Jiagang Deng
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Jiagang Deng
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Jiagang Deng
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Jiagang Deng
- Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases, Guangxi University of Chinese Medicine, Nanning, China
- Erwei Hao
- Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, China
- Erwei Hao
- Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Nanning, China
- Erwei Hao
- Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues, Nanning, China
- Erwei Hao
- Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases, Guangxi University of Chinese Medicine, Nanning, China
- DOI
- https://doi.org/10.3389/fgene.2023.1166831
- Journal volume & issue
-
Vol. 14
Abstract
As a neurodegenerative disease, Alzheimer’s disease (AD) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. Various biological processes are affected by epitranscriptomic modifications, which regulate the metabolism of mRNA in cells and regulate the expression of genes. In response to changes in m6A modification levels, the nervous system becomes dysfunctional and plays a significant role in the development of Alzheimer’s disease. As a result of recent research, this paper reviews advances in the understanding of the regulatory mechanisms of m6A modification in the occurrence and development of AD. In addition, the article discusses recent research techniques related to animal models of m6A and AD. Furthermore, it discusses the possibility of studying the pathogenesis of AD at the level of the epitranscriptome, identifying early diagnostic markers, and screening for effective treatment options.
Keywords
