Nature Communications (Feb 2021)

Self-assembly and regulation of protein cages from pre-organised coiled-coil modules

  • Fabio Lapenta,
  • Jana Aupič,
  • Marco Vezzoli,
  • Žiga Strmšek,
  • Stefano Da Vela,
  • Dmitri I. Svergun,
  • José María Carazo,
  • Roberto Melero,
  • Roman Jerala

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12


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Coiled-coil protein origami is a strategy for the de novo design of polypeptide nanostructures based on coiled-coil dimer forming peptides, where a single chain protein folds into a polyhedral cage. Here, the authors design a single-chain triangular bipyramid and also demonstrate that the bipyramid can be self-assembled as a heterodimeric complex, comprising pre-defined subunits.