A comparative study on the efficacy of brinzolamide/timolol versus brinzolamide/brimonidine fixed drug combinations in primary open-angle glaucoma

Abstract

Abstract Background To compare the efficacy of brinzolamide 1%/timolol 0.5% fixed drug combination (BTFC) with brinzolamide 1%/brimonidine 0.2% fixed drug combination (BBFC) among the patients with primary open-angle glaucoma (POAG). Results The treatment with BTFC in the Group A subjects showed a significant decrease in the intraocular pressure (p = 0.0355*) and a significant increase in the central corneal thickness (p = 0.0087*). Similarly, in the Group B subjects, the treatment with BBFC showed a significant decrease in the intraocular pressure (p = 0.0327*) and a significant increase in the central corneal thickness (p = 0.0227*). In the process of comparing both the fixed drug combinations, there was no significant difference observed in the aspect of efficacy between both the groups in the decrease of intraocular pressure (p = 0.7100) and in the increase of central corneal thickness (p = 0.4077). Conclusion Both the fixed drug combinations almost showed a similar efficacy in treating the respective groups, and there is no significant difference observed in the aspect of efficacy between both the fixed drug combinations in decreasing the intraocular pressure and in increasing the central corneal thickness.

Keywords

• Brimonidine
• Brinzolamide
• Glaucoma
• Pachymeter
• Timolol