Nature Communications (Mar 2022)
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma
- Claudia Capparelli,
- Timothy J. Purwin,
- McKenna Glasheen,
- Signe Caksa,
- Manoela Tiago,
- Nicole Wilski,
- Danielle Pomante,
- Sheera Rosenbaum,
- Mai Q. Nguyen,
- Weijia Cai,
- Janusz Franco-Barraza,
- Richard Zheng,
- Gaurav Kumar,
- Inna Chervoneva,
- Ayako Shimada,
- Vito W. Rebecca,
- Adam E. Snook,
- Kim Hookim,
- Xiaowei Xu,
- Edna Cukierman,
- Meenhard Herlyn,
- Andrew E. Aplin
Affiliations
- Claudia Capparelli
- Department of Cancer Biology, Thomas Jefferson University
- Timothy J. Purwin
- Department of Cancer Biology, Thomas Jefferson University
- McKenna Glasheen
- Department of Cancer Biology, Thomas Jefferson University
- Signe Caksa
- Department of Cancer Biology, Thomas Jefferson University
- Manoela Tiago
- Department of Cancer Biology, Thomas Jefferson University
- Nicole Wilski
- Department of Cancer Biology, Thomas Jefferson University
- Danielle Pomante
- Department of Cancer Biology, Thomas Jefferson University
- Sheera Rosenbaum
- Department of Cancer Biology, Thomas Jefferson University
- Mai Q. Nguyen
- Department of Cancer Biology, Thomas Jefferson University
- Weijia Cai
- Department of Cancer Biology, Thomas Jefferson University
- Janusz Franco-Barraza
- Cancer Signaling and Epigenetics Program, Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center
- Richard Zheng
- Department of Surgery, Thomas Jefferson University
- Gaurav Kumar
- Department of Cancer Biology, Thomas Jefferson University
- Inna Chervoneva
- Division of Biostatistics, Thomas Jefferson University
- Ayako Shimada
- Division of Biostatistics, Thomas Jefferson University
- Vito W. Rebecca
- Melanoma Research Center, The Wistar Institute
- Adam E. Snook
- Sidney Kimmel Cancer Center, Thomas Jefferson University
- Kim Hookim
- Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University
- Xiaowei Xu
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Edna Cukierman
- Cancer Signaling and Epigenetics Program, Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center
- Meenhard Herlyn
- Melanoma Research Center, The Wistar Institute
- Andrew E. Aplin
- Department of Cancer Biology, Thomas Jefferson University
- DOI
- https://doi.org/10.1038/s41467-022-28801-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Mechanisms underlying tumor cell plasticity remain poorly understood. Here, the authors show the presence of a dormant-invasive SOX10- subpopulation in cutaneous melanoma that can be targeted by cIAP1/2 inhibitors.
