Nature Communications (Mar 2023)
A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
- Chong Wang,
- Xiang Liu,
- Jun Liang,
- Yohei Narita,
- Weiyue Ding,
- Difei Li,
- Luyao Zhang,
- Hongbo Wang,
- Merrin Man Long Leong,
- Isabella Hou,
- Catherine Gerdt,
- Chang Jiang,
- Qian Zhong,
- Zhonghui Tang,
- Carmy Forney,
- Leah Kottyan,
- Matthew T. Weirauch,
- Benjamin E. Gewurz,
- Mu-sheng Zeng,
- Sizun Jiang,
- Mingxiang Teng,
- Bo Zhao
Affiliations
- Chong Wang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Xiang Liu
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute
- Jun Liang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Yohei Narita
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Weiyue Ding
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Difei Li
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Luyao Zhang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Hongbo Wang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Merrin Man Long Leong
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Isabella Hou
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Catherine Gerdt
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Chang Jiang
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Qian Zhong
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Zhonghui Tang
- Zhongshan School of Medicine, Sun Yat-sen University
- Carmy Forney
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Leah Kottyan
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Matthew T. Weirauch
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Benjamin E. Gewurz
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Mu-sheng Zeng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center
- Sizun Jiang
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center and Harvard Medical School
- Mingxiang Teng
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute
- Bo Zhao
- Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-023-37347-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
The dynamic and temporal changes of host genome architecture during Epstein-Barr virus (EBV) transformation are not well known. Here the authors transform human primary B lymphocyte into lymphoblastoid cell lines (LCLs) with EBV and show that the host 3D genome is rewired to facilitate expression of key oncogenes.
