Терапевтический архив (Jul 2020)

Monoclonal gammapathy of renal significance (MGRS) at the current state: terminology, diagnosis and treatment

  • Lidia V. Lysenko (Kozlovskaya),
  • Vilen V. Rameev,
  • Tatyana V. Androsova

DOI
https://doi.org/10.26442/00403660.2020.06.000666
Journal volume & issue
Vol. 92, no. 6
pp. 15 – 22

Abstract

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In this article we discussed the current state of monoclonal gammapathy of renal significance (Monoclonal Gammopathy of Renal Significance MGRS) and revealed problems of B-cell clone secreting nephrotoxic monoclonal immunoglobulin identification. We followed 276 patients with monoclonal gammapathy including patients with non-amyloid nephropathy. The majority of patients had systemic AL-amyloidosis. We established better survival of the treated patients with systemic AL-amyloidosis in comparison with retrospective untreated cohort. We considered current treatment of patients with non-amyloid nephropathy and focused on the crucial role of multidisciplinary approach in management of these patients.

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