Nature Communications (Jan 2020)
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh
- Limin Zhao,
- Hao Ke,
- Haibo Xu,
- Guo-Dong Wang,
- Honglei Zhang,
- Li Zou,
- Shu Xiang,
- Mengyuan Li,
- Li Peng,
- Mingfang Zhou,
- Lingling Li,
- Lei Ao,
- Qin Yang,
- Che-Kun James Shen,
- Ping Yi,
- Lu Wang,
- Baowei Jiao
Affiliations
- Limin Zhao
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Hao Ke
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Haibo Xu
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Guo-Dong Wang
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Honglei Zhang
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Li Zou
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Shu Xiang
- The First Hospital of Kunming, Calmette International Hospital
- Mengyuan Li
- Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University
- Li Peng
- Yubei District Maternal and Child Health Care Hospital
- Mingfang Zhou
- Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University
- Lingling Li
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Lei Ao
- Kunming Angel Women’s and Children’s Hospital
- Qin Yang
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- Che-Kun James Shen
- Institute of Molecular Biology, Academia Sinica
- Ping Yi
- Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University
- Lu Wang
- State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Yunnan University
- Baowei Jiao
- State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-019-14183-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. Here the authors found that TDP-43, a RNA-binding protein, is required for milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh mRNA stability.
