Nature Communications (Dec 2022)
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
- Lynne Krohn,
- Karl Heilbron,
- Cornelis Blauwendraat,
- Regina H. Reynolds,
- Eric Yu,
- Konstantin Senkevich,
- Uladzislau Rudakou,
- Mehrdad A. Estiar,
- Emil K. Gustavsson,
- Kajsa Brolin,
- Jennifer A. Ruskey,
- Kathryn Freeman,
- Farnaz Asayesh,
- Ruth Chia,
- Isabelle Arnulf,
- Michele T. M. Hu,
- Jacques Y. Montplaisir,
- Jean-François Gagnon,
- Alex Desautels,
- Yves Dauvilliers,
- Gian Luigi Gigli,
- Mariarosaria Valente,
- Francesco Janes,
- Andrea Bernardini,
- Birgit Högl,
- Ambra Stefani,
- Abubaker Ibrahim,
- Karel Šonka,
- David Kemlink,
- Wolfgang Oertel,
- Annette Janzen,
- Giuseppe Plazzi,
- Francesco Biscarini,
- Elena Antelmi,
- Michela Figorilli,
- Monica Puligheddu,
- Brit Mollenhauer,
- Claudia Trenkwalder,
- Friederike Sixel-Döring,
- Valérie Cochen De Cock,
- Christelle Charley Monaca,
- Anna Heidbreder,
- Luigi Ferini-Strambi,
- Femke Dijkstra,
- Mineke Viaene,
- Beatriz Abril,
- Bradley F. Boeve,
- 23andMe Research Team,
- Sonja W. Scholz,
- Mina Ryten,
- Sara Bandres-Ciga,
- Alastair Noyce,
- Paul Cannon,
- Lasse Pihlstrøm,
- Mike A. Nalls,
- Andrew B. Singleton,
- Guy A. Rouleau,
- Ronald B. Postuma,
- Ziv Gan-Or
Affiliations
- Lynne Krohn
- Department of Human Genetics, McGill University
- Karl Heilbron
- 23andMe, Inc.
- Cornelis Blauwendraat
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Regina H. Reynolds
- Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London
- Eric Yu
- Department of Human Genetics, McGill University
- Konstantin Senkevich
- Department of Human Genetics, McGill University
- Uladzislau Rudakou
- Department of Human Genetics, McGill University
- Mehrdad A. Estiar
- Department of Human Genetics, McGill University
- Emil K. Gustavsson
- Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London
- Kajsa Brolin
- Lund University, Translational Neurogenetics Unit, Department of Experimental Medical Science
- Jennifer A. Ruskey
- The Neuro (Montreal Neurological Institute-Hospital), McGill University
- Kathryn Freeman
- The Neuro (Montreal Neurological Institute-Hospital), McGill University
- Farnaz Asayesh
- The Neuro (Montreal Neurological Institute-Hospital), McGill University
- Ruth Chia
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Isabelle Arnulf
- Sleep Disorders Unit, Pitié Salpêtrière Hospital, APHP-Sorbonne, Paris Brain Insitute and Sorbonne University
- Michele T. M. Hu
- Oxford Parkinson’s Disease Centre (OPDC), University of Oxford
- Jacques Y. Montplaisir
- Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal
- Jean-François Gagnon
- Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal
- Alex Desautels
- Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal
- Yves Dauvilliers
- National Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Institute Neuroscience Montpellier Inserm
- Gian Luigi Gigli
- Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine
- Mariarosaria Valente
- Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine
- Francesco Janes
- Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine
- Andrea Bernardini
- Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine
- Birgit Högl
- Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck
- Ambra Stefani
- Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck
- Abubaker Ibrahim
- Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck
- Karel Šonka
- Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital
- David Kemlink
- Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital
- Wolfgang Oertel
- Department of Neurology, Philipps-University
- Annette Janzen
- Department of Neurology, Philipps-University
- Giuseppe Plazzi
- Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia
- Francesco Biscarini
- Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna
- Elena Antelmi
- IRCCS, Institute of Neurological Sciences of Bologna
- Michela Figorilli
- Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari
- Monica Puligheddu
- Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari
- Brit Mollenhauer
- Paracelsus-Elena-Klinik
- Claudia Trenkwalder
- Paracelsus-Elena-Klinik
- Friederike Sixel-Döring
- Department of Neurology, Philipps-University
- Valérie Cochen De Cock
- Sleep and Neurology Unit, Beau Soleil Clinic
- Christelle Charley Monaca
- University Lille North of France, Department of Clinical Neurophysiology and Sleep Center, CHU Lille
- Anna Heidbreder
- Institute of Sleep Medicine and Neuromuscular Disorders, University of Münster
- Luigi Ferini-Strambi
- Department of Neurological Sciences, Università Vita-Salute San Raffaele
- Femke Dijkstra
- Laboratory for Sleep Disorders, St. Dimpna Regional Hospital
- Mineke Viaene
- Laboratory for Sleep Disorders, St. Dimpna Regional Hospital
- Beatriz Abril
- Sleep disorder Unit, Carémeau Hospital, University Hospital of Nîmes
- Bradley F. Boeve
- Department of Neurology, Mayo Clinic
- 23andMe Research Team
- Sonja W. Scholz
- Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke
- Mina Ryten
- Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London
- Sara Bandres-Ciga
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Alastair Noyce
- Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London
- Paul Cannon
- 23andMe, Inc.
- Lasse Pihlstrøm
- Department of Neurology, Oslo University Hospital
- Mike A. Nalls
- Data Tecnica International
- Andrew B. Singleton
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Guy A. Rouleau
- Department of Human Genetics, McGill University
- Ronald B. Postuma
- The Neuro (Montreal Neurological Institute-Hospital), McGill University
- Ziv Gan-Or
- Department of Human Genetics, McGill University
- DOI
- https://doi.org/10.1038/s41467-022-34732-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
REM-sleep behavior disorder often precedes Parkinson’s disease or dementia. Here, the authors perform a genome-wide association study for REM-sleep behavior disorder, and discover how it potentially affects gene expression in the brain.
