Clinical Interventions in Aging (Jul 2022)
Superoxide Dismutase and Glutathione Reductase as Indicators of Oxidative Stress Levels May Relate to Geriatric Hip Fractures’ Survival and Walking Ability: A Propensity Score Matching Study
Abstract
Mingchong Liu,1,* Chensong Yang,1,* Qining Chu,2 Xiao Fu,1 Yue Zhang,1 Guixin Sun1 1Department of Traumatic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Emergency Trauma Center, Nanyang Second General Hospital, Nanyang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guixin Sun, Department of Traumatic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China, Tel +21-38804518, Fax +21-65983047, Email [email protected]: Oxidative stress status may affect bone metabolism and regeneration. However, few studies reported whether oxidative stress could impact the outcomes of hip fractures. This study aimed to explore if superoxide dismutase and glutathione reductase, the critical antioxidant enzymes, correlated with the prognosis of hip fractures.Methods: Patients with hip fractures were extracted from our database, and those who met the inclusion criteria were analyzed. Propensity score matching was used to reduce the influence of confounding factors, and ROC curves based on matched populations were created to determine the optimal cutoff points of SOD and GR. Then, outcomes between SOD or GR and outcomes of hip fractures were compared.Results: Out of 301 patients enrolled in this study, 50 patients died within one year. After a 1:1 PSM, the patients with less than 1-year survival had significantly lower SOD (p = 0.026) and GR (p = 0.021) than those who were still alive at one year. Logistics analysis showed that low SOD and low GR may be independent risk factors for 6-month survival, 1-year survival, 6-month free walking ability, and 1-year free walking ability.Conclusion: SOD and GR may be the independent risk factors for survival and walking abilities of hip fractures.Keywords: hip fractures, oxidative stress, superoxide dismutase, glutathione reductases, prognosis
