Different gene alterations in patients with non-small-cell lung cancer between the eastern and southern China
Chengdong Liu,
Kangbao Li,
Yi Sui,
Hongmei Liu,
Yunzhi Zhang,
Yuan Lu,
Wei Lu,
Yongfeng Chen,
Gehui Wang,
Suqian Xu,
Tianmin Xiang,
Yongguang Cai,
Kenan Huang
Affiliations
Chengdong Liu
Department of thoracic surgery, Naval Medical Center of PLA, 338 Huaihai Road, Changning District, Shanghai 200052, China
Kangbao Li
Department of Geriatrics, Gastroenterology Ward, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China
Yi Sui
Singlera Genomics Inc., Shanghai 201318, China
Hongmei Liu
Singlera Genomics Inc., Shanghai 201318, China
Yunzhi Zhang
Singlera Genomics Inc., Shanghai 201318, China
Yuan Lu
Medical Oncology Department V, Central Hospital of Guangdong Nongken 524002, China
Wei Lu
Medical Oncology Department V, Central Hospital of Guangdong Nongken 524002, China
Yongfeng Chen
Medical Oncology Department V, Central Hospital of Guangdong Nongken 524002, China
Gehui Wang
Singlera Genomics Inc., Shanghai 201318, China
Suqian Xu
Singlera Genomics Inc., Shanghai 201318, China
Tianmin Xiang
Singlera Genomics Inc., Shanghai 201318, China
Yongguang Cai
Medical Oncology Department V, Central Hospital of Guangdong Nongken 524002, China; Corresponding author.
Kenan Huang
Department of Thoracic Surgery, Shanghai Changzheng Hospital, Navy Military Medical University, 415 Fengyang Road, Huangpu District, Shanghai 200003, China; Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Corresponding author. Department of Thoracic Surgery, Shanghai Changzheng Hospital, Navy Military Medical University, 415 Fengyang Road, Huangpu District, Shanghai 200003, China.
Geographical differences are conspicuous in lung cancer, and the distinct molecular features of lung tumor between Western patients and Asian patients have been demonstrated. However, the etiology of non-small-cell lung cancer (NSCLC) and the distribution of associated molecular aberrations in China have not been fully elucidated. The mutational profiles of 12 lung cancer-related genes were investigated in 85 patients from eastern China and 88 patients from southern China who had been histologically confirmed NSCLC. Overall, 93.6% (162/173) of tumor samples harbored at least one somatic alteration. The most frequently mutated genes were TP53 (56.1%), EGFR (50.3%), and KRAS (14.5%). We found that EGFR mutated much more frequently (60.0% vs 40.9%, P = 0.012) and TP53 mutations had significantly lower incidence (47.1% vs 64.8%, P = 0.019) in eastern cohort than that in southern cohort. Mutational signature analysis revealed a region-related mutagenesis mechanism characterized by a high prevalence of C to T transitions mainly occurring at CpG dinucleotides in southern patients. This study reveals the difference in the mutational features between NSCLC patients in eastern and southern China. The distinct patterns of gene mutation could provide clues for the mechanism of carcinogenesis of lung cancer, offering opportunities to stratify patients into optimal treatment plans based on genomic profiles.
